Abstract:

In the present work, we report on the solubilization of gabapentin (GBP) into lyotropic hexagonal mesophases composed of monoolein, tricaprylin, and water. It was demonstrated that the hexagonal structure remained intact up to 2 wt. % gabapentin, whereas the lamellar phase coexisted with the hexagonal one in the concn. range of 3-4 wt. % of the drug. At gabapentin content of 5-6 wt. %, only lamellar phases contg. defects such as dislocations and multilamellar vesicles were detected. Incorporation of GBP decreased the lattice parameter of the HII mesophase from 56.6 to 50.6 \AA, while the structural dimensions of the lamellar phase were not affected. ATR-FTIR anal. suggested enhanced hydrogen bonding between the protonated amine of GBP and the O-H groups of the GMO and the water surrounding in the inner hydrophilic interface region. This led to intercalation of the drug into the water-lipid interface. At higher GBP loads of 4-6 wt. %, thermal anal. revealed disordering within the lipid packing, apparently induced by the spatially altered interface area. Rheol. measurements correlated the macroscopic features of the systems with alterations on the mol. level and allowed distinguishing between closely related mesophases due to their different rheol. characteristics. In vitro transdermal delivery studies showed that the examd. mesophases enabled a sustained release of GBP compared to its aq. soln. Sustained release was more pronounced in the case of the hexagonal mesophase, compared to the lamellar one. [on SciFinder(R)]