New crystal forms of lamotrigine and processes for their preparations.

Citation:

Nissim Garti, Berkovich, Yana , Dolitzky, Ben-Zion , Aronhime, Judith , Singer, Claude , Lieberman, Anita , and Gershon, Neomi. . 2002. “New Crystal Forms Of Lamotrigine And Processes For Their Preparations.”. Canada CA2439468.

Abstract:

The present invention relates to lamotrigine, a useful agent for anti-epilepsia. New crystal forms of lamotrigine-contg. mols. of the solvent in stoichiometric ratios are disclosed. Processes for prepg. the new crystal forms of lamotrigine and dosage forms are also provided. For example, 2 g of lamotrigine anhyd. and about 80 mL of ethanol were charged in a three-necked bottomed round flask equipped with a mech. stirrer, a condenser and a thermometer. The suspension was stirred for about 24 h without heating at about 25° and the solid phase was sepd. by filtration, producing lamotrigine Form H, i.e., lamotrigine ethanol monosolvate. [on SciFinder(R)]
Last updated on 05/27/2020