Abstract:

A review. This article reviews the creation of advanced drug delivery nano systems (aDDnSs) comprised of liposomes and polymers focusing on the interactions of the structural components and their biomedical applications. ADDnSs have been shown to significantly: (a) increase the load of the bioactive substance into the system, which is very important both for manufg.-economic reasons and for toxicity reasons (as less quantity of carrier is used for the same amt. of drug), (b) lower the release rate of the encapsulate drug, a fact that could create a more controlled and/or sustained release profile of the drug in the bloodstream, leading to lower toxicity and higher effectiveness (c) advanced pharmacol. toxicity compared to the free drug and at least equal toxicity compared to the resp. conventional liposomal formulation. A plethora of physicochem. data has begun to shed light to the interactions of the components of these complicate systems that seem to be responsible for the advantages presented by the aDDnSs. [on SciFinder(R)]