Abstract:

Multiple emulsions of H2O-in-oil-in-H2O (W/O/W) were used to overcome the unpleasant taste of drugs such as chlorpromazine-HCl [69-09-0]. The drug was dissolved in the inner H2O phase and was released throughout the oil phase in the presence of synthetic gastric juice. Inner (I) and outer (II) emulsifiers were used. A combination of anionic-nonionic emulsifiers such as 8 wt.% Brij 93 [9004-98-2] as I and 3 wt.% Span 20 [1338-39-2] + Tween 80 [9005-65-6] + triethanolamine oleate [2717-15-9] as II (anionic-nonionic 1:4) gave high yield of prepn., high stability and complete release of drug in synthetic gastric juice. [on SciFinder(R)]