Abstract:

The formation of amorphous calcium phosphate (ACP) and its transformation into octacalcium phosphate (OCP) in the presence of poly-L-glutamic acid (PGA, Mw 3000 Da and 50,000 Da), poly-L-lysine (Mw 50,000 Da) and polystyrene sulfonate (MW 70,000 Da) has been investigated. All polyelectrolytes at low concns. induced and at high concns. retarded nucleation of the cryst. ppt. In addn., the polyelectrolytes inhibited aggregation of ACP particles and growth of the cryst. phase. The intensity of the effects depended on the charge, mol. mass, and concn. of the specific polymer. [on SciFinder(R)]