Abstract:

The effect of various org. solvents and crystn. conditions on the crystal habit of anhyd. cholesterol was studied. Both plates and needle-like crystals can be obtained in a particular solvent depending on the degree of supersatn. of the soln. However, the crystals grown at about the same supersatn., from different solvents, show differences in their habit indicating dependence on the solvent-solute interaction. Thus, it is advisable not to identify needle-like crystals with anhyd.-cholesterol and plates with monohydrate cholesterol without specifying the crystn. conditions. A prediction on the crystal habit length to width ratios can be made using these parameters. [on SciFinder(R)]