Do food microemulsions and dietary mixed micelles interact?.

Citation:

Shoshana Rozner, Shalev, Deborah E, Shames, Alexander I, Ottaviani, Maria Francesca , Aserin, Abraham , and Garti, Nissim. . 2010. “Do Food Microemulsions And Dietary Mixed Micelles Interact?”. Colloids And Surfaces, B: Biointerfaces, 77, 1, Pp. 22–30. doi:10.1016/j.colsurfb.2009.12.026.

Abstract:

Using microemulsions (ME) as delivery vehicles requires understanding whether water-insol. mols. are delivered by an interaction of the ME system with the dietary mixed micelles (DMM) in the small intestine to give new mixed micelles, or by alternate paths. Dild. DMM and ME systems were mixed at various wt. ratios to address this question. The individual and mixed systems were characterized by phys. techniques that address this interaction from different aspects. This research showed that increased DMM concn. in ME/DMM mixed systems caused: (1) increased conformational order of the acyl chains and perturbed hydrogen bonds between the ethoxylate headgroups (based on ATR-FTIR results); (2) significant increase in microviscosity (from 1.7 to 3.3 ns) (based on EPR results); (3) increased diffusivity of the surfactant mols. compared to their diffusivity in pure ME droplets, and decreased diffusivity of the taurochenodeoxycholate mols. compared to their diffusivities in pure DMM micelles (based on PGSE-NMR results); (4) formation or modification of intramol. interactions (based on NOESY-NMR results); (5) decreased av. droplet diam. and increased droplet d. per unit area compared to pure ME systems (based on DLS and cryo-TEM results); and (6) fluorescence resonance energy transfer between two dyes (diphenylhexatriene and Nile Red), which were solubilized in each system sep. (based on fluorescence resonance energy transfer results). These results show that DMM and ME interact to create ME-DMM mixed micelles, providing a potential pathway for delivering solubilized mols. [on SciFinder(R)]

Last updated on 05/27/2020