Abstract:

Crystal size distribution and the yield of Ca oxalate crystals were detd. in solns. with an admixt. of 5 normal and 3 stone forming urines. A pos. correlation was found between the median size and no. of particles and the overall inhibitory potentials of the urines toward Ca oxalate pptn. in vitro as reflected by discriminating index (DI) [sic] measurements. Incubation of 2 samples of stone formers' (SF) urines with glutamic-oxalacetic-transaminase (GOT) caused a redn. of aspartic acid concn., an increase in glutamic acid concn. and a parallel decrease in the DI values. After 90 min of SF urine incubation with GOT the DI in three samples was improved and both the median size and no. of particles were reduced, by 28% and 45% resp. These results could indicate that GOT activity changes the inhibitory power of the SF urine by transforming aspartic acid into glutamic acid, having thus most probably a part in the inhibition of Ca oxalate stone formation. [on SciFinder(R)]