Abstract:

In this communication we demonstrate for the first time that lyotropic reverse hexagonal mesophase can serve as a crystn. medium for a hydrophobic peptide, resulting in high quality single crystals suitable for crystallog. anal. The obtained crystals of cyclosporin A enabled excellent X-ray data collection, diffracting to a resoln. limit of 1.0 \AA. Current findings open a new perspective in the field of crystn. of biol. macromols. in lyotropic mesophases. [on SciFinder(R)]