Abstract:

Celecoxib belongs to a new NSAID family specifically inhibiting cyclooxygenase-2 (COX-2). The present formulations require high dosage since the transmembrane transport fluctuates and is very difficult to control. The authors solubilized celecoxib in micelles of nonionic microemulsions and hydrophilic surfactant. The supersatd. solubilized drug was pptd. from the nano-droplets to form a new solid structure with improved dissoln. properties. The selected microemulsion systems loaded with celecoxib were characterized by SAXS, SD-NMR, viscosity, and elec. cond. techniques. Pptn. was conducted from W/O as well as from O/W U-type microemulsions. The crystals obtained by the pptn. were characterized by x-ray powder scattering, differential scanning calorimetry, FTIR measurements, and microscopic scans. [on SciFinder(R)]