Control of calcium phosphate crystal nucleation, growth and morphology by polyelectrolytes


H Furedi-Milhofer, PBY Ofir, M Sikiric, and N Garti. 2004. “Control of calcium phosphate crystal nucleation, growth and morphology by polyelectrolytes.” In BIOCERAMICS 16, edited by MA Barbosa, FJ Monteiro, R Correia, and B Leon, 254-2: Pp. 11–14. Fund Ciencia & Tecnol; Cipan; Univ Porto, Fac Engenhar; Reitoria Univ Porto; INEB Inst Engenhar Biomed.


Crystal growth of calcium hydrogenphosphate dihydrate (DCPD), in the presence of polyaspartic acid or calcium phytate (system A), as well as nucleation and growth of octacalcium phosphate (OCP), in the presence of poly-l-lysine, poly-l-glutamic acid or polystyrene sulfonate (system B) have been investigated. In system A crystallization of DCPD was inhibited and the crystal growth morphology was specifically modified by preferential interaction of the respective additive with the dominant (010) crystal face. In system B crystals were formed via precursor phase(s) and polyelectrolytes exhibited dual action, at low concentrations inducing and at high concentrations inhibiting nucleation of the crystalline phase. Crystal/additive interactions controlling growth were nonspecific and resulted in smaller crystals with rounded edges, but with the same basic orientation as in the controls.
Last updated on 05/27/2020