Abstract:

A review on immunonanoparticles (immunoNPs) as promising drug-targeting, colloidal carriers, that can ensure the specific recognition of the antigen site and, using the colloidal delivery system, release cytotoxic agents close to the inaccessible pathol. target tissues-over-expressing tumor antigen. The main approaches used for the coupling of monoclonal antibodies (MAbs) to NPs are reviewed. In addn., the preclin. achievements of NP formulations conjugated to various MAbs are described and updated. Also addressed is the synergistic importance of the MAbs as targeting moieties on immunoNP formulations as compds. that not only target specific pathol. organs, but also ensure increased therapeutic activity of the drug-loaded NPs by actually internalizing them within the desired cells. [on SciFinder(R)]