Basic principles of drug delivery systems - the case of paclitaxel.


S Ezrahi, A Aserin, and N Garti. 2019. “Basic principles of drug delivery systems - the case of paclitaxel.” Advances in Colloid and Interface Science, 263, Pp. 95–130.


Cancer is the second cause of death worldwide, exceeded only by cardiovascular diseases. The prevalent treatment currently used against metastatic cancer is chemotherapy. Among the most studied drugs that inhibit neoplastic cells from acquiring unlimited replicative ability (a hallmark of cancer) are the taxanes. They operate via a unique mol. mechanism affecting mitosis. In this review, we show this mechanism for one of them, paclitaxel, and for other (non-taxanes) anti-mitotic drugs. However, the use of paclitaxel is seriously limited (its bioavailability is \textless10%) due to several long-standing challenges: its poor water soly. (0.3 $μ$g/mL), its being a substrate for the efflux multidrug transporter P-gp, and, in the case of oral delivery, its first-pass metab. by certain enzymes. Adequate delivery methods are therefore required to enhance the anti-tumor activity of paclitaxel. Thus, we have also reviewed drug delivery strategies in light of the various phys., chem., and enzymic obstacles facing the (esp. oral) delivery of drugs in general and paclitaxel in particular. Among the powerful and versatile platforms that have been developed and achieved unprecedented opportunities as drug carriers, microemulsions might have great potential for this aim. This is due to properties such as thermodn. stability (leading to long shelf-life), increased drug solubilization, and ease of prepn. and administration. In this review, we define microemulsions and nanoemulsions, analyze their pertinent properties, and review the results of several drug delivery carriers based on these systems. [on SciFinder(R)]
Last updated on 05/27/2020